Modeling DNA beacons at the mesoscopic scale
نویسندگان
چکیده
منابع مشابه
Modeling DNA beacons at the mesoscopic scale.
We report model calculations on DNA single strands which describe the equilibrium dynamics and kinetics of hairpin formation and melting. Modeling is at the level of single bases. Strand rigidity is described in terms of simple polymer models; alternative calculations performed using the freely rotating chain and the discrete Kratky-Porod models are reported. Stem formation is modeled according...
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We report here on the hybridization of peptide nucleic acid (PNA)-based molecular beacons (MB) directly to duplex DNA sites locally exposed by PNA openers. Two stemless PNA beacons were tested, both featuring the same recognition sequence and fluorophore-quencher pair (Fluorescein and DABCYL, respectively) but differing in arrangement of these groups and net electrostatic charge. It was found t...
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ژورنال
عنوان ژورنال: The European Physical Journal E
سال: 2007
ISSN: 1292-8941,1292-895X
DOI: 10.1140/epje/i2007-10200-x